Prediction of miscarriage in first trimester by serum estradiol, progesterone and β-human chorionic gonadotropin within 9 weeks of gestation
Purpose: To predict miscarriage outcome within 12 weeks of gestational age by evaluating values of serum estradiol, progesterone and β-human chorionic gonadotropin (β-HCG) within 9 weeks of gestation. Methods: One hundred sixty-five women with singleton pregnancies were retrospectively studied. Estradiol, progesterone and β-HCG levels were measured at 5-6 weeks of gestation and the measurements were repeated…
Read MoreA technical and clinical evaluation of the new ThermoFisher BRAHMS unconjugated estriol and inhibin-A assays and their use in second trimester Down syndrome screening
To evaluate second-trimester Down syndrome screening performance of the new ThermoFisher BRAHMS GOLD unconjugated estriol (uE3) and inhibin-A assays. Serum samples were analyzed for levels of uE3 and inhibin-A using the ThermoFisher BRAHMS GOLD immunoanalyzer and compared to other platforms. Levels were transformed to multiples of the median (MoM) in unaffected pregnancies. Log10 MoM distributions…
Read MoreUnexpected discovery of estrone in the rotational spectrum of estradiol: a systematic investigation of a CP-FTMW spectrum
We report the reinvestigation of the high-resolution rotational spectrum of estradiol. After removing the known spectral lines corresponding to three conformers of estradiol identified in the gas phase before, a large number of spectral lines remained unassigned in the spectrum. The observation of remaining lines is a common feature in spectra obtained by broadband rotational…
Read MoreAlgorithms with Area under the Curve for Daily Urinary Estrone–3–Glucuronide and Pregnanediol-3–Glucuronide to Signal the Transition to the Luteal Phase
Background and Objectives: Home fertility assessment methods (FAMs) for natural family planning (NFP) have technically evolved with the objective metrics of urinary luteinizing hormone (LH), estrone-3-glucuronide (E3G) and pregnanediol-3-glucuronide (PDG). Practical and reliable algorithms for timing the phase of cycle based upon E3G and PDG levels are mostly unpublished and still lacking. Materials and Methods:…
Read MoreThe EDA deficient mouse has Zymbal’s gland hypoplasia and acute otitis externa
In mice, rats, dogs and humans the growth and function of sebaceous glands and eyelid Meibomian glands depend on the ectodysplasin signalling pathway. Mutation of genes encoding the ligand EDA, its transmembrane receptor EDAR, and the intracellular signal transducer EDARADD leads to Hypohidrotic Ectodermal Dysplasia characterised by impaired development of teeth and hair as well as…
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Genomic Epidemiology and Evolution of Escherichia coli in Wild Animals in Mexico
Escherichia coli is a typical bacterial species within the gastrointestinal tracts of warm-blooded animals and people. Pathogenicity and antimicrobial resistance in E. coli could emerge through host switching from animal reservoirs. Regardless of its potential medical significance, information of the inhabitants construction of commensal E. coli inside wild hosts and the epidemiological hyperlinks between E. coli in nonhuman hosts and E. coli in people…
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Etiology of atherosclerosis informs choice of animal models and tissues for initial functional genomic studies of resveratrol.
Resveratrol, a phytoalexin, is a pure polyphenol synthesized completely by crops in response to environmental stresses. Nonetheless, the molecule has additionally many exogenous bioactivities in animal cells. These bioactivities might result in anti-cancer and cardio-protective well being advantages. As a result of mobile responses to the therapy with resveratrol embody the modifications of expression patterns,…
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Genomic Analysis of Staphylococcus aureus of the Lineage CC130, Including mecC-Carrying MRSA and MSSA Isolates Recovered of Animal, Human, and Environmental Origins
Most methicillin resistant Staphylococcus aureus (MRSA) isolates harboring mecC gene belong to clonal advanced CC130. This lineage has historically been considered animal-associated because it lacks the human particular immune evasion cluster (IEC), and has been recovered from a broad vary of animal hosts. However, sporadic mecC-MRSA human infections have been reported, with proof of zoonotic transmission in some instances. The…
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MolluscDB: an integrated functional and evolutionary genomics database for the hyper-diverse animal phylum Mollusca
Mollusca represents the second largest animal phylum however stays poorly explored from a genomic perspective. Whereas the latest enhance in genomic sources holds nice promise for a deep understanding of molluscan biology and evolution, entry and utilization of those sources nonetheless pose a problem. Right here, we current the primary complete molluscan genomics database, MolluscDB…
Read MoreGenMark ePlex Controls
The ePlex SARS-CoV-2 Test is intended for the qualitative detection of SARS-CoV-2 nucleic acid in nasopharyngeal swab specimens (NPS) eluted in viral transport media (VTM) collected from individuals suspected of COVID-19 by their health care provider. Testing is limited to laboratories certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA), 42 U.S.C. § 263a,…
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