Tag: dna ancestry
Interference on Cytosolic DNA Activation Attenuates Sepsis Severity: Experiments on Cyclic GMP-AMP Synthase (cGAS) Deficient Mice
- Paul
- 0
Although the enhanced responses against serum cell-free DNA (cfDNA) in cases of sepsis-a life-threatening organ dysfunction due to systemic infection-are understood, the influence of the cytosolic DNA receptor cGAS (cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthase) on sepsis is still unclear. Here, experiments on cGAS deficient (cGAS-/-) mice were conducted using cecal ligation and puncture (CLP)…
Read MoreGenomic Analysis of Staphylococcus aureus of the Lineage CC130, Including mecC-Carrying MRSA and MSSA Isolates Recovered of Animal, Human, and Environmental Origins
- Paul
- 0
Most methicillin resistant Staphylococcus aureus (MRSA) isolates harboring mecC gene belong to clonal advanced CC130. This lineage has historically been considered animal-associated because it lacks the human particular immune evasion cluster (IEC), and has been recovered from a broad vary of animal hosts. However, sporadic mecC-MRSA human infections have been reported, with proof of zoonotic transmission in some instances. The…
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