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Involvement of c-Jun N-terminal kinase 2 (JNK2) in Endothelin–1 (ET–1) Mediated Neurodegeneration of Retinal Ganglion Cells
Purpose: The goal of this study was to determine whether JNK2 played a causative role in endothelin-mediated loss of RGCs in mice. Methods: JNK2-/- and wild type (C57BL/6) mice were intravitreally injected in one eye with 1 nmole of ET-1, whereas the contralateral eye was injected with the vehicle. At two time points (two hours and…
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