Involvement of c-Jun N-terminal kinase 2 (JNK2) in Endothelin1 (ET1) Mediated Neurodegeneration of Retinal Ganglion Cells

Purpose: The goal of this study was to determine whether JNK2 played a causative role in endothelin-mediated loss of RGCs in mice. Methods: JNK2-/- and wild type (C57BL/6) mice were intravitreally injected in one eye with 1 nmole of ET-1, whereas the contralateral eye was injected with the vehicle. At two time points (two hours and…

Read More