Genomic, Transcriptomic and Epigenomic Tools to Study the Domestication of Plants and Animals: A Field Guide for Beginners
Within the final decade, genomics and the associated fields of transcriptomics and epigenomics have revolutionized the examine of the domestication course of in vegetation and animals, resulting in new discoveries and new unresolved questions. Provided that some domesticated taxa have been extra studied than others, the extent of genomic knowledge can vary from huge to nonexistent, relying on the domesticated taxon of curiosity.
This assessment is supposed as a tough information for college students and lecturers that need to begin a domestication analysis undertaking utilizing trendy genomic instruments, in addition to for researchers already conducting domestication research which can be fascinated with following a genomic method and in search of alternate methods (cheaper or extra environment friendly) and future instructions.
We summarize the theoretical and technical background wanted to hold out domestication genomics, ranging from the acquisition of a reference genome and genome meeting, to the sampling design for inhabitants genomics, paleogenomics, transcriptomics, epigenomics and experimental validation of domestication-related genes. We additionally describe some examples of the aforementioned approaches and the related discoveries they made to grasp the domestication of the studied taxa.
Genomic epidemiology of animal-derived tigecycline-resistant Escherichia coli throughout China reveals current endemic plasmid-encoded tet(X4) gene
Public well being interventions to manage the current emergence of plasmid-mediated tigecycline resistance genes depend on a complete understanding of its epidemiology and distribution over a variety of geographical scales. Right here we analysed an Escherichia coli assortment remoted from pigs and chickens in China in 2018, and ascertained that the tet(X4) gene was not current at excessive prevalence throughout China, however was extremely endemic in northwestern China.
Genomic evaluation of tet(X4)-positive E. coli demonstrated a current and regional dissemination of tet(X4) amongst numerous clonal backgrounds and plasmids in northwestern China, whereas a parallel epidemic coincided with the impartial acquisition of tet(X4) in E. coli from the remaining provinces. The excessive genetic similarity of tet(X4)-positive E. coli and human commensal E. coli suggests the potential for its spreading into people. Our examine gives a scientific evaluation of the present epidemiology of tet(X4) and identifies priorities for optimising well timed intervention methods.
Practical Genomics of Epileptogenesis in Animal Fashions and People
It has been estimated that epilepsies are among the many high 5 neurological ailments with the best burden of illness. Lately, genome-wide expression research (GWES) have been carried out in experimental fashions of epilepsy and in samples from human sufferers. On this examine, I carried out meta-analyses and analyses of convergence for out there GWES for epileptogenesis in people and in mouse, rat, zebrafish and fruit fly fashions. A number of strains of proof (similar to genome-wide affiliation knowledge and identified druggable genes) have been built-in to prioritize high candidate genes for epileptogenesis and a purposeful enrichment evaluation was carried out.
A number of high candidate genes, that are supported by a number of strains of genomic proof, similar to GRIN1, KCNAB1 and STX1B, have been recognized. Druggable genes of potential curiosity (similar to GABRA2, GRIK1, KCNAB1 and STX4) have been additionally recognized. An enrichment of genes regulated by the MEF2 and SOX5 transcription elements and the miR-106b-5p and miR-101-3p miRNAs was discovered. The present work is the primary meta-analysis and convergent evaluation of GWES for epileptogenesis in people and in a number of animal fashions, integrating outcomes from a number of genomic research. Novel candidate genes and pathways for epileptogenesis have been recognized on this evaluation.
Tracing animal genomic evolution with the chromosomal-level meeting of the freshwater sponge Ephydatia muelleri
The genomes of non-bilaterian metazoans are key to understanding the molecular foundation of early animal evolution. Nevertheless, a full comprehension of how animal-specific traits, similar to nervous techniques, arose is hindered by the shortage and fragmented nature of genomes from key taxa, similar to Porifera. Ephydatia muelleri is a freshwater sponge discovered throughout the northern hemisphere. Right here, we current its 326 Mb genome, assembled to excessive contiguity (N50: 9.88 Mb) with 23 chromosomes on 24 scaffolds.
Our analyses reveal a metazoan-typical genome structure, with extremely shared synteny throughout Metazoa, and recommend that adaptation to the intense temperatures and circumstances present in freshwater typically includes gene duplication. The pancontinental distribution and prepared laboratory tradition of E. muelleri make this a extremely sensible mannequin system which, with RNAseq, DNA methylation and bacterial amplicon knowledge spanning its improvement and vary, permits exploration of genomic modifications each inside sponges and in early animal evolution.
Estimation of Genomic Breed Composition for Purebred and Crossbred Animals Utilizing Sparsely Regularized Admixture Fashions
Quite a lot of statistical strategies, similar to admixture fashions, have been used to estimate genomic breed composition (GBC). These strategies, nonetheless, have a tendency to supply non-zero parts to reference breeds that shared some genomic similarity with a check animal. These non-essential GBC parts, in flip, offset the estimated GBC for the breed to which it belongs. Because of this, not all purebred animals have 100% GBC of their respective breeds, which statistically signifies an elevated false-negative charge within the identification of purebred animals with 100% GBC because the cutoff.
In any other case, a decrease cutoff of estimated GBC should be used, which is bigoted, and the outcomes are much less interpretable. Within the current examine, three admixture fashions with regularization have been proposed, which produced sparse options by way of suppressing the noise within the estimated GBC because of genomic similarities.
The regularization or penalty varieties included the L1 norm penalty, minimax concave penalty (MCP), and easy clipped absolute deviation (SCAD). The performances of those regularized admixture fashions on the estimation of GBC have been examined in purebred and composite animals, respectively, and in comparison with that of the non-regularized admixture mannequin because the baseline mannequin.
The outcomes confirmed that, given optimum values for λ, the three sparsely regularized admixture fashions had increased energy and thus lowered the false-negative charge for the breed identification of purebred animals than the non-regularized admixture mannequin. Of the three regularized admixture fashions, the 2 with a non-convex penalty outperformed the one with L1 norm penalty.
Zyxin (ZYX) Antibody |
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| abx433465-200ul | Abbexa | 200 ul | EUR 460.8 |
Zyxin (ZYX) Antibody |
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| abx239764-100ug | Abbexa | 100 ug | EUR 661.2 |
Zyxin (ZYX) Antibody |
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| abx239765-100ug | Abbexa | 100 ug | EUR 610.8 |
Zyxin (ZYX) Antibody |
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| 20-abx175170 | Abbexa |
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Human Zyxin (ZYX) Protein |
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| 20-abx069720 | Abbexa |
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Human Zyxin (ZYX) Protein |
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| 20-abx069721 | Abbexa |
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Zyxin (ZYX) Antibody (Biotin) |
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| 20-abx272263 | Abbexa |
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Zyxin (ZYX) Antibody (FITC) |
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| 20-abx273635 | Abbexa |
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Human Zyxin (ZYX) ELISA Kit |
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| 20-abx153537 | Abbexa |
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Human Zyxin (ZYX) CLIA Kit |
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| 20-abx493561 | Abbexa |
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Human Zyxin (ZYX) ELISA Kit |
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| abx555876-96tests | Abbexa | 96 tests | EUR 801.6 |
Human Zyxin(ZYX) ELISA kit |
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| CSB-EL027165HU-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
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Description: Quantitativesandwich ELISA kit for measuring Human Zyxin (ZYX) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Human Zyxin(ZYX) ELISA kit |
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| 1-CSB-EL027165HU | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Zyxin(ZYX) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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Human Zyxin, ZYX ELISA KIT |
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| ELI-53492h | Lifescience Market | 96 Tests | EUR 988.8 |
Zyxin (ZYX) Monoclonal Antibody (Human) |
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| 4-MAC235Hu21 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Zyxin (ZYX) |
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Human ZYX/ Zyxin ELISA Kit |
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| E2725Hu | Sunlong | 1 Kit | EUR 726 |
Human Zyxin(ZYX)ELISA Kit |
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| GA-E1505HM-48T | GenAsia Biotech | 48T | EUR 346.8 |
Human Zyxin(ZYX)ELISA Kit |
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| GA-E1505HM-96T | GenAsia Biotech | 96T | EUR 559.2 |
Zyxin (ZYX) Polyclonal Antibody (Human) |
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| 4-PAC235Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX) |
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Zyxin (ZYX) Polyclonal Antibody (Human) |
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| 4-PAC235Hu02 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX) |
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Human Zyxin (ZYX) ELISA Kit |
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| SEC235Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5677.8 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Zyxin (ZYX) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Human Zyxin (ZYX) ELISA Kit |
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| SEC235Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 572.76 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Zyxin (ZYX) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Human Zyxin (ZYX) ELISA Kit |
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| SEC235Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 766.8 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Zyxin (ZYX) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Human Zyxin (ZYX) ELISA Kit |
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| SEC235Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3090.6 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Zyxin (ZYX) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Human Zyxin (ZYX) ELISA Kit |
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| 4-SEC235Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Zyxin (ZYX) in samples from tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. |
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Human Zyxin(ZYX)ELISA Kit |
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| QY-E04229 | Qayee Biotechnology | 96T | EUR 433.2 |
Human Zyxin ELISA Kit (ZYX) |
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| RK02541 | Abclonal | 96 Tests | EUR 625.2 |
ELISA kit for Human ZYX (Zyxin) |
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| ELK4891 | ELK Biotech | 1 plate of 96 wells | EUR 518.4 |
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Description: A sandwich ELISA kit for detection of Zyxin from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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Zyxin (ZYX) Monoclonal Antibody (Human), APC |
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| 4-MAC235Hu21-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Zyxin (ZYX). This antibody is labeled with APC. |
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Zyxin (ZYX) Monoclonal Antibody (Human), Biotinylated |
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| 4-MAC235Hu21-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Zyxin (ZYX). This antibody is labeled with Biotin. |
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Zyxin (ZYX) Monoclonal Antibody (Human), Cy3 |
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| 4-MAC235Hu21-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Zyxin (ZYX). This antibody is labeled with Cy3. |
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Zyxin (ZYX) Monoclonal Antibody (Human), FITC |
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| 4-MAC235Hu21-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Zyxin (ZYX). This antibody is labeled with FITC. |
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Zyxin (ZYX) Monoclonal Antibody (Human), HRP |
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| 4-MAC235Hu21-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Zyxin (ZYX). This antibody is labeled with HRP. |
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Zyxin (ZYX) Monoclonal Antibody (Human), PE |
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| 4-MAC235Hu21-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Zyxin (ZYX). This antibody is labeled with PE. |
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ELISA kit for Human Zyxin (ZYX) |
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| KTE62447-48T | Abbkine | 48T | EUR 398.4 |
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Description: Quantitative sandwich ELISA for measuring Human Zyxin (ZYX) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Human Zyxin (ZYX) |
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| KTE62447-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2538 |
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Description: Quantitative sandwich ELISA for measuring Human Zyxin (ZYX) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Human Zyxin (ZYX) |
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| KTE62447-96T | Abbkine | 96T | EUR 646.8 |
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Description: Quantitative sandwich ELISA for measuring Human Zyxin (ZYX) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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Zyxin (ZYX) Polyclonal Antibody (Human), APC |
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| 4-PAC235Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX). This antibody is labeled with APC. |
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Zyxin (ZYX) Polyclonal Antibody (Human), Biotinylated |
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| 4-PAC235Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX). This antibody is labeled with Biotin. |
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Zyxin (ZYX) Polyclonal Antibody (Human), Cy3 |
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| 4-PAC235Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX). This antibody is labeled with Cy3. |
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Zyxin (ZYX) Polyclonal Antibody (Human), FITC |
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| 4-PAC235Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX). This antibody is labeled with FITC. |
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Zyxin (ZYX) Polyclonal Antibody (Human), HRP |
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| 4-PAC235Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX). This antibody is labeled with HRP. |
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Zyxin (ZYX) Polyclonal Antibody (Human), PE |
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| 4-PAC235Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX). This antibody is labeled with PE. |
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Zyxin (ZYX) Polyclonal Antibody (Human), APC |
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| 4-PAC235Hu02-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX). This antibody is labeled with APC. |
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Zyxin (ZYX) Polyclonal Antibody (Human), Biotinylated |
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| 4-PAC235Hu02-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX). This antibody is labeled with Biotin. |
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Zyxin (ZYX) Polyclonal Antibody (Human), Cy3 |
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| 4-PAC235Hu02-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX). This antibody is labeled with Cy3. |
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Zyxin (ZYX) Polyclonal Antibody (Human), FITC |
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| 4-PAC235Hu02-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX). This antibody is labeled with FITC. |
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Zyxin (ZYX) Polyclonal Antibody (Human), HRP |
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| 4-PAC235Hu02-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX). This antibody is labeled with HRP. |
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Zyxin (ZYX) Polyclonal Antibody (Human), PE |
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| 4-PAC235Hu02-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX). This antibody is labeled with PE. |
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Chicken Zyxin (ZYX) ELISA Kit |
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| abx555364-96tests | Abbexa | 96 tests | EUR 1093.2 |
Mouse Zyxin (ZYX) ELISA Kit |
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| abx556120-96tests | Abbexa | 96 tests | EUR 801.6 |
Mouse Zyxin, Zyx ELISA KIT |
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| ELI-40811m | Lifescience Market | 96 Tests | EUR 1038 |
Chicken Zyxin, ZYX ELISA KIT |
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| ELI-14746c | Lifescience Market | 96 Tests | EUR 1113.6 |
Zyxin (ZYX) Monoclonal Antibody (Human), APC-Cy7 |
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| 4-MAC235Hu21-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Zyxin (ZYX). This antibody is labeled with APC-Cy7. |
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Zyxin (ZYX) Polyclonal Antibody (Human), APC-Cy7 |
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| 4-PAC235Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX). This antibody is labeled with APC-Cy7. |
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Zyxin (ZYX) Polyclonal Antibody (Human), APC-Cy7 |
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| 4-PAC235Hu02-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Zyxin (ZYX). This antibody is labeled with APC-Cy7. |
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Zyxin Phospho-Ser142 (ZYX pS142) Antibody |
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| 20-abx324004 | Abbexa |
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Zyx ELISA Kit| Mouse Zyxin ELISA Kit |
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| EF016536 | Lifescience Market | 96 Tests | EUR 826.8 |
ZYX ELISA Kit| chicken Zyxin ELISA Kit |
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| EF012568 | Lifescience Market | 96 Tests | EUR 826.8 |
ZYX Recombinant Protein (Human) |
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| RP036337 | ABM | 100 ug | Ask for price |
ZYX Recombinant Protein (Rat) |
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| RP238847 | ABM | 100 ug | Ask for price |
ZYX Recombinant Protein (Mouse) |
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| RP188411 | ABM | 100 ug | Ask for price |
Alleleustrious pmTFP1-Zyxin fusion vector Zyxin |
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| ABP-FP-TZY | Allele Biotech | 5 ug | Ask for price |
Alleleustrious pWasabi-Zyxin fusion vector Zyxin |
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| ABP-FP-WZY | Allele Biotech | 5 ug | Ask for price |
Zyxin Antibody |
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| 39205-100ul | SAB | 100ul | EUR 468 |
Zyxin Antibody |
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| 49705-100ul | SAB | 100ul | EUR 399.6 |
Zyxin Antibody |
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| 49705-50ul | SAB | 50ul | EUR 286.8 |
Zyxin Antibody |
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| AF7902 | Affbiotech | 200ul | EUR 540 |
Zyxin Antibody |
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| AF7903 | Affbiotech | 200ul | EUR 540 |
Zyxin Antibody |
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| DF6858 | Affbiotech | 200ul | EUR 420 |
anti-Zyxin |
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| YF-PA25007 | Abfrontier | 50 ul | EUR 400.8 |
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Description: Mouse polyclonal to Zyxin |
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anti-Zyxin |
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| YF-PA15457 | Abfrontier | 50 ul | EUR 435.6 |
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Description: Mouse polyclonal to Zyxin |
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anti-Zyxin |
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| YF-PA15458 | Abfrontier | 50 ug | EUR 435.6 |
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Description: Mouse polyclonal to Zyxin |
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anti-Zyxin |
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| YF-PA15459 | Abfrontier | 100 ug | EUR 483.6 |
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Description: Rabbit polyclonal to Zyxin |
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Zyxin Antibody |
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| R35413-100UG | NSJ Bioreagents | 100 ug | EUR 399 |
ZYX Antibody |
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| 43893-100ul | SAB | 100ul | EUR 302.4 |
ZYX Peptide |
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| 42-257P | ProSci | 0.1 mg | EUR 405.6 |
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Description: (IN) ZYX Peptide |
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ZYX antibody |
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| 70R-21425 | Fitzgerald | 50 ul | EUR 522 |
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Description: Rabbit polyclonal ZYX antibody |
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ZYX antibody |
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| 38377-100ul | SAB | 100ul | EUR 302.4 |
ZYX Antibody |
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| ABD6858 | Lifescience Market | 100 ug | EUR 525.6 |
ZYX siRNA |
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| 20-abx941267 | Abbexa |
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ZYX siRNA |
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| 20-abx941268 | Abbexa |
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ZYX Antibody |
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| 1-CSB-PA027165GA01HU | Cusabio |
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Description: A polyclonal antibody against ZYX. Recognizes ZYX from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
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Zyxin ELISA KIT|Human |
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| EF004535 | Lifescience Market | 96 Tests | EUR 826.8 |
Human Zyxin ELISA kit |
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| E01Z0034-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Human Zyxin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Zyxin ELISA kit |
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| E01Z0034-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Human Zyxin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Zyxin ELISA kit |
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| E01Z0034-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Human Zyxin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human ZYX shRNA Plasmid |
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| 20-abx955275 | Abbexa |
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Recombinant Human Zyxin Protein, His, Mammal-100ug |
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| QP10108-ma-100ug | EnQuireBio | 100ug | EUR 1413.6 |
Recombinant Human Zyxin Protein, His, Mammal-20ug |
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| QP10108-ma-20ug | EnQuireBio | 20ug | EUR 554.4 |
Recombinant Human Zyxin Protein, His, Mammal-50ug |
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| QP10108-ma-50ug | EnQuireBio | 50ug | EUR 1034.4 |
Zyxin antibody (Ser142) |
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| 70R-34606 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Purified Rabbit polyclonal Zyxin antibody (Ser142) |
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Zyxin Blocking Peptide |
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| AF7902-BP | Affbiotech | 1mg | EUR 234 |
Zyxin Blocking Peptide |
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| AF7903-BP | Affbiotech | 1mg | EUR 234 |
Zyxin Conjugated Antibody |
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| C49705 | SAB | 100ul | EUR 476.4 |
Anti-Zyxin antibody |
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| PAab09764 | Lifescience Market | 100 ug | EUR 494.4 |
anti- Zyxin antibody |
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| FNab09764 | FN Test | 100µg | EUR 702 |
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Description: Antibody raised against Zyxin |
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anti- Zyxin antibody |
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| FNab09765 | FN Test | 100µg | EUR 658.5 |
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Description: Antibody raised against Zyxin |
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Anti-Zyxin (2D1) |
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| YF-MA11026 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to Zyxin |
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ZYX Rabbit pAb |
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| A2135-100ul | Abclonal | 100 ul | EUR 369.6 |
ZYX Rabbit pAb |
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| A2135-200ul | Abclonal | 200 ul | EUR 550.8 |
ZYX Rabbit pAb |
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| A2135-20ul | Abclonal | 20 ul | EUR 219.6 |
ZYX Rabbit pAb |
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| A2135-50ul | Abclonal | 50 ul | EUR 267.6 |
ZYX Blocking Peptide |
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| DF6858-BP | Affbiotech | 1mg | EUR 234 |
ZYX cloning plasmid |
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| CSB-CL027165HU-10ug | Cusabio | 10ug | EUR 451.2 |
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Description: A cloning plasmid for the ZYX gene. |
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ZYX Conjugated Antibody |
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| C43893 | SAB | 100ul | EUR 476.4 |
ZYX Conjugated Antibody |
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| C38377 | SAB | 100ul | EUR 476.4 |
Anti-ZYX antibody |
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| STJ26156 | St John's Laboratory | 100 µl | EUR 332.4 |
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Description: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. |
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Anti-ZYX antibody |
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| STJ72081 | St John's Laboratory | 100 µg | EUR 430.8 |
ZYX ELISA Kit (Human) (OKEH08197) |
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| OKEH08197 | Aviva Systems Biology | 96 Wells | EUR 1075.2 |
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Description: Description of target: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 29pg/mL |
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ZYX ORF Vector (Human) (pORF) |
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| ORF012113 | ABM | 1.0 ug DNA | EUR 114 |
ZYX ELISA Kit (Human) (OKCA02157) |
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| OKCA02157 | Aviva Systems Biology | 96 Wells | EUR 999.6 |
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Description: Description of target: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 5.8 pg/mL |
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ZYX ELISA Kit (Human) (OKCD00316) |
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| OKCD00316 | Aviva Systems Biology | 96 Wells | EUR 997.2 |
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Description: Description of target: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).By similarity ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.061 ng/mL |
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Zyxin (Phospho-Tyr316) Antibody |
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| 13247-100ul | SAB | 100ul | EUR 302.4 |
Zyxin (Phospho-Tyr316) Antibody |
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| 13247-50ul | SAB | 50ul | EUR 224.4 |
Zyxin (Phospho-Ser143) Antibody |
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| 13248-100ul | SAB | 100ul | EUR 302.4 |
Within the Brangus, a composite cattle breed, estimated GBC have been roughly comparable among the many 4 admixture fashions, however all of the 4 fashions underestimated the GBC for these composite animals when non-ancestral breeds have been included because the reference. In conclusion, the admixture fashions with sparse regularization gave extra parsimonious, constant and interpretable outcomes of estimated GBC for purebred animals than the non-regularized admixture mannequin. However, the utility of regularized admixture fashions for estimating GBC in crossbred or composite animals must be taken with warning.
