MolluscDB: an integrated functional and evolutionary genomics database for the hyper-diverse animal phylum Mollusca
- Paul
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Mollusca represents the second largest animal phylum however stays poorly explored from a genomic perspective. Whereas the latest enhance in genomic sources holds nice promise for a deep understanding of molluscan biology and evolution, entry and utilization of those sources nonetheless pose a problem. Right here, we current the primary complete molluscan genomics database, MolluscDB , which compiles and integrates present molluscan genomic/transcriptomic sources and offers handy instruments for multi-level integrative and comparative genomic analyses.
MolluscDB allows a scientific view of genomic info from varied elements, comparable to genome meeting statistics, genome phylogenies, fossil data, gene info, expression profiles, gene households, transcription components, transposable parts and mitogenome group info. Furthermore, MolluscDB provides beneficial custom-made datasets or sources, comparable to gene coexpression networks throughout varied developmental levels and grownup tissues/organs, core gene repertoires inferred for main molluscan lineages, and macrosynteny evaluation for chromosomal evolution.
MolluscDB presents an integrative and complete genomics platform that can enable the molluscan neighborhood to deal with ever-growing genomic sources and can expedite new scientific discoveries for understanding molluscan biology and evolution.
A Causality Perspective of Genomic Breed Composition for Composite Animals
Genomic breed composition (GBC) of a person animal refers back to the partition of its genome in response to the inheritance from its ancestors or ancestral breeds. For crossbred or composite animals, realizing their GBC is helpful to estimate heterosis, to characterize their precise inheritance from basis breeds, and to make administration selections for crossbreeding applications. Numerous statistical approaches have been proposed to estimate GBC in animals, however the interpretations of estimates have various with these strategies. Within the current research, we proposed a causality interpretation of GBC primarily based on path evaluation.
We utilized this technique to estimating GBC in two composite breeds of beef cattle, particularly Brangus and Beefmaster. Three SNP panels have been used to estimate GBC: a 10Ok SNP panel consisting of 10,226 frequent SNPs throughout three GeneSeek Genomic Profiler (GGP) bovine SNP arrays (GGP 30Ok, GGP 40Ok, and GGP 50Ok), and two subsets (1K and 5K) of uniformly distributed SNPs. The trail evaluation decomposed the relationships between the ancestors and the composite animals into direct and oblique path results, and GBC was measured by the relative ratio of the coefficients of direct (D-GBC) and mixed (C-GBC) results from every ancestral breed to the progeny, respectively.
Estimated GBC various solely barely between totally different genotyping platforms and between the three SNP panels. Within the Brangus cattle, as a result of the 2 ancestral breeds had a really distant relationship, the estimated D-GBC and C-GBC have been comparable to one another within the path evaluation, and so they corresponded roughly to the estimated GBC from the linear regression and the admixture mannequin.
Within the Beefmaster, nevertheless, the robust relationship in allelic frequencies between Hereford and Shorthorn imposed a problem for the linear regression and the admixture mannequin to estimated GBC reliably. As an alternative, D-GBC by the trail evaluation included solely direct ancestral results, and it was strong to bias attributable to excessive genomic correlations between reference (ancestral) breeds.
Genomic Options of Parthenogenetic Animals
Evolution with out intercourse is predicted to impression genomes in quite a few methods. Case research of particular person parthenogenetic animals have reported peculiar genomic options that have been advised to be brought on by their mode of replica, together with excessive heterozygosity, a excessive abundance of horizontally acquired genes, a low transposable ingredient load, or the presence of palindromes. We systematically characterised these genomic options in revealed genomes of 26 parthenogenetic animals representing a minimum of 18 unbiased transitions to asexuality.
Surprisingly, not a single function was systematically replicated throughout a majority of those transitions, suggesting that beforehand reported patterns have been lineage-specific slightly than illustrating the overall penalties of parthenogenesis. We discovered that solely parthenogens of hybrid origin have been characterised by excessive heterozygosity ranges. Parthenogens that weren’t of hybrid origin seemed to be largely homozygous, unbiased of the mobile mechanism underlying parthenogenesis.
General, regardless of the significance of recombination price variation for the evolution of sexual animal genomes, the genome-wide absence of recombination doesn’t seem to have had the dramatic results that are anticipated from classical theoretical fashions. The explanations for this are in all probability a mix of lineage-specific patterns, the impression of the origin of parthenogenesis, and a survivorship bias of parthenogenetic lineages.
Comparative Genomic Evaluation of 450 Strains of Salmonella enterica Remoted from Diseased Animals
Salmonella is a number one explanation for bacterial infections in animals and people. We sequenced a group of 450 Salmonella strains from diseased animals to raised perceive the genetic make-up of their virulence and resistance options. The presence of Salmonella pathogenicity islands (SPIs) various by serotype. S. Enteritidis carried essentially the most SPIs (n = 15), whereas S. Mbandaka, S. Cerro, S. Meleagridis, and S. Havana carried the least (n = 10). S. Typhimurium, S. Choleraesuis, S. I 4,5,12:i:-, and S. Enteritidis every contained the spv operon on IncFII or IncFII-IncFIB hybrid plasmids. Two S. IIIa carried a spv operon with spvD deletion on the chromosome.
Twelve plasmid varieties together with 24 hybrid plasmids have been recognized. IncA/C was continuously related to S. Newport (83%) and S. Agona (100%) from bovine, whereas IncFII (100%), IncFIB (100%), and IncQ1 (94%) have been seen in S. Choleraesuis from swine. IncX (100%) was detected in all S. Kentucky from hen. A complete of 60 antimicrobial resistance genes (ARGs), 4 disinfectant resistances genes (DRGs) and 33 heavy metallic resistance genes (HMRGs) have been recognized.
Recombinant Human Glutaminase kidney isoform, mitochondrial(GLS),partial |
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AP74300 | SAB | 1mg | EUR 2826 |
Recombinant Human Glutaminase kidney isoform, mitochondrial(GLS),partial |
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AP74310 | SAB | 1mg | EUR 2826 |
Glutaminase kidney isoform, mitochondrial |
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AP79068 | SAB | 1mg | EUR 2640 |
Glutaminase kidney isoform, mitochondrial |
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AP83270 | SAB | 1mg | EUR 2640 |
Glutaminase kidney isoform, mitochondrial |
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AP83568 | SAB | 1mg | EUR 2640 |
Rat Glutaminase kidney isoform mitochondrial, Gls ELISA KIT |
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ELI-12701r | Lifescience Market | 96 Tests | EUR 1063.2 |
Human Glutaminase kidney isoform, mitochondrial (GLS) |
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1-CSB-EP009528HU(F) | Cusabio |
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Description: Recombinant Human Glutaminase kidney isoform, mitochondrial(GLS),partial expressed in E.coli |
Human Glutaminase kidney isoform, mitochondrial (GLS) |
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1-CSB-EP009528HU(F1) | Cusabio |
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Description: Recombinant Human Glutaminase kidney isoform, mitochondrial(GLS),partial expressed in E.coli |
Rat Gls / Glutaminase kidney isoform, mitochondrial ELISA Kit |
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E15055r | EIAab | 96T | EUR 796 |
Rat Glutaminase kidney isoform,mitochondria, GLS GENLISA ELISA |
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KLR1984 | Krishgen | 1 x 96 wells | EUR 341 |
Glutaminase Kidney Isoform, Mitochondrial (GLS) Antibody |
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abx234518-100ug | Abbexa | 100 ug | EUR 577.2 |
Glutaminase Kidney Isoform, Mitochondrial (GLS) Antibody |
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abx234519-100ug | Abbexa | 100 ug | EUR 610.8 |
Glutaminase Kidney Isoform, Mitochondrial (GLS) Antibody |
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abx234518-100g | Abbexa | 100 µg | EUR 350 |
Glutaminase Kidney Isoform, Mitochondrial (GLS) Antibody |
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abx234519-100g | Abbexa | 100 µg | EUR 350 |
Gls ELISA Kit| Rat Glutaminase kidney isoform, mitochondrial EL |
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EF018741 | Lifescience Market | 96 Tests | EUR 826.8 |
Human Glutaminase kidney isoform, mitochondrial ELISA Kit |
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EK3615 | SAB | 96 tests | EUR 739 |
Human GLS/ Glutaminase kidney isoform, mitochondrial ELISA Kit |
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E1023Hu | Sunlong | 1 Kit | EUR 515 |
Description: GLS1,KIAA0838,K-glutaminase,L-glutamine amidohydrolase |
Human GLS(Glutaminase kidney isoform, mitochondrial) ELISA Kit |
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EKF59189-48T | Biomatik Corporation | 48T | EUR 396.9 |
Human GLS(Glutaminase kidney isoform, mitochondrial) ELISA Kit |
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EKF59189-5x96T | Biomatik Corporation | 5x96T | EUR 2693.25 |
Human GLS(Glutaminase kidney isoform, mitochondrial) ELISA Kit |
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EKF59189-96T | Biomatik Corporation | 96T | EUR 567 |
Human GLS(Glutaminase kidney isoform, mitochondrial) ELISA Kit |
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EH1742 | FN Test | 96T | EUR 681.12 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml |
Human Glutaminase kidney isoform mitochondrial(GLS) ELISA Kit |
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NSL1245Hu | Sunlong | 96 wells | EUR 468 |
Human Glutaminase kidney isoform, mitochondrial (GLS) ELISA Kit |
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RK11040 | Abclonal | 96T | EUR 280 |
Human GLS / Glutaminase kidney isoform, mitochondrial ELISA Kit |
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E15055h | EIAab | 96T | EUR 736 |
Mouse Gls / Glutaminase kidney isoform, mitochondrial ELISA Kit |
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E15055m | EIAab | 96T | EUR 776 |
Bovine Glutaminase kidney isoform mitochondrial(GLS) ELISA Kit |
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NSL1390Bo | Sunlong | 96 T | EUR 528 |
Canine Glutaminase kidney isoform mitochondrial(GLS) ELISA Kit |
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NSL1414Ca | Sunlong | 1509 wells | EUR 528 |
Recombinant Human Glutaminase liver isoform, mitochondrial (GLS2) |
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CSB-EP887058HU | Cusabio | 4750 mg | Ask for price |
Recombinant Human Glutaminase liver isoform, mitochondrial(GLS2) |
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AP74311 | SAB | 1mg | EUR 2826 |
Recombinant Human Glutaminase liver isoform, His-SUMO, E.coli-1mg |
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QP8210-ec-1mg | EnQuireBio | 1mg | EUR 2763.6 |
Recombinant Human Glutaminase liver isoform, His-SUMO, E.coli-100ug |
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QP8210-ec-100ug | EnQuireBio | 100ug | EUR 685.2 |
Recombinant Human Glutaminase liver isoform, His-SUMO, E.coli-10ug |
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QP8210-ec-10ug | EnQuireBio | 10ug | EUR 326.4 |
Recombinant Human Glutaminase liver isoform, His-SUMO, E.coli-200ug |
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QP8210-ec-200ug | EnQuireBio | 200ug | EUR 1077.6 |
Recombinant Human Glutaminase liver isoform, His-SUMO, E.coli-500ug |
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QP8210-ec-500ug | EnQuireBio | 500ug | EUR 1816.8 |
Recombinant Human Glutaminase liver isoform, His-SUMO, E.coli-50ug |
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QP8210-ec-50ug | EnQuireBio | 50ug | EUR 434.4 |
Rat Gls2 / Glutaminase liver isoform, mitochondrial ELISA Kit |
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E13728r | EIAab | 96T | EUR 796 |
Gls2 ELISA Kit| Rat Glutaminase liver isoform, mitochondrial EL |
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EF018742 | Lifescience Market | 96 Tests | EUR 826.8 |
Human Glutaminase liver isoform, mitochondrial (GLS2) |
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1-CSB-EP887058HU | Cusabio |
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Description: Recombinant Human Glutaminase liver isoform, mitochondrial(GLS2) expressed in E.coli |
Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody |
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20-abx311936 | Abbexa |
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Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody |
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20-abx126919 | Abbexa |
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Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody |
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abx032915-400ul | Abbexa | 400 ul | EUR 627.6 |
Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody |
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abx032915-80l | Abbexa | 80 µl | EUR 343.2 |
Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody |
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abx032915-400l | Abbexa | 400 µl | EUR 518.75 |
Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody |
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abx311936-100g | Abbexa | 100 µg | EUR 362.5 |
Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody |
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abx311936-20g | Abbexa | 20 µg | EUR 162.5 |
Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody |
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abx311936-50g | Abbexa | 50 µg | EUR 250 |
Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody (HRP) |
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20-abx311937 | Abbexa |
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Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody (HRP) |
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abx311937-100g | Abbexa | 100 µg | EUR 362.5 |
Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody (HRP) |
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abx311937-20g | Abbexa | 20 µg | EUR 162.5 |
Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody (HRP) |
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abx311937-50g | Abbexa | 50 µg | EUR 250 |
Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody (FITC) |
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20-abx311938 | Abbexa |
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Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody (FITC) |
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abx311938-100g | Abbexa | 100 µg | EUR 362.5 |
Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody (FITC) |
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abx311938-20g | Abbexa | 20 µg | EUR 162.5 |
Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody (FITC) |
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abx311938-50g | Abbexa | 50 µg | EUR 250 |
Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody (Biotin) |
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20-abx311939 | Abbexa |
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Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody (Biotin) |
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abx311939-100g | Abbexa | 100 µg | EUR 362.5 |
Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody (Biotin) |
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abx311939-20g | Abbexa | 20 µg | EUR 162.5 |
Glutaminase Liver Isoform, Mitochondrial (GLS2) Antibody (Biotin) |
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abx311939-50g | Abbexa | 50 µg | EUR 250 |
Gls2 ELISA Kit| Mouse Glutaminase liver isoform, mitochondrial |
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EF015050 | Lifescience Market | 96 Tests | EUR 826.8 |
Mouse Glutaminase liver isoform, mitochondrial, Gls2 ELISA KIT |
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ELI-27365m | Lifescience Market | 96 Tests | EUR 1038 |
Human Glutaminase liver isoform, mitochondrial, GLS2 ELISA KIT |
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ELI-20970h | Lifescience Market | 96 Tests | EUR 988.8 |
Human Glutaminase liver isoform, mitochondrial (GLS2) ELISA Kit |
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abx392226-96tests | Abbexa | 96 tests | EUR 1093.2 |
Human Glutaminase liver isoform, mitochondrial (GLS2) ELISA Kit |
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RK11149 | Abclonal | 96T | EUR 280 |
Human Glutaminase liver isoform, mitochondrial (GLS2) ELISA Kit |
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abx392226-200g | Abbexa | 200 µg | EUR 687.5 |
Human GLS2 / Glutaminase liver isoform, mitochondrial ELISA Kit |
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E13728h | EIAab | 96T | EUR 736 |
Mouse Gls2 / Glutaminase liver isoform, mitochondrial ELISA Kit |
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E13728m | EIAab | 96T | EUR 776 |
Recombinant Glutaminase (GLS) |
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RPU52328-100ug | Biomatik Corporation | 100ug | EUR 517 |
Recombinant Glutaminase (GLS) |
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RPU52328-1mg | Biomatik Corporation | 1mg | EUR 2293.2 |
Recombinant Glutaminase (GLS) |
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RPU52328-50ug | Biomatik Corporation | 50ug | EUR 415.8 |
Recombinant Glutaminase (GLS) |
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RPJ026Hu01 | Cloud-Clone | 10ug | EUR 152 |
Recombinant Glutaminase (GLS) |
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4-RPJ026Hu01 | Cloud-Clone |
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Description: Recombinant Human Glutaminase expressed in: E.coli |
Recombinant Glutaminase (GLS) |
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RPJ026Mu01 | Cloud-Clone | 10ug | EUR 168 |
Recombinant Glutaminase (GLS) |
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4-RPJ026Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Glutaminase expressed in: E.coli |
Recombinant Glutaminase (GLS) |
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RPJ026Ra01 | Cloud-Clone | 10ug | EUR 140 |
Recombinant Glutaminase (GLS) |
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RPU51232-100ug | Biomatik Corporation | 100ug | EUR 468.6 |
Recombinant Glutaminase (GLS) |
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RPU51232-1mg | Biomatik Corporation | 1mg | EUR 2074.8 |
Recombinant Glutaminase (GLS) |
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RPU51232-50ug | Biomatik Corporation | 50ug | EUR 376.2 |
Recombinant Glutaminase (GLS) |
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RPU58633-100ug | Biomatik Corporation | 100ug | EUR 602.3 |
Recombinant Glutaminase (GLS) |
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RPU58633-1mg | Biomatik Corporation | 1mg | EUR 2795.5 |
Recombinant Glutaminase (GLS) |
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RPU58633-50ug | Biomatik Corporation | 50ug | EUR 468.2 |
Recombinant E.Coli Glutaminase 1 |
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7-02857 | CHI Scientific | 5µg | Ask for price |
Recombinant E.Coli Glutaminase 1 |
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7-02858 | CHI Scientific | 20µg | Ask for price |
Recombinant E.Coli Glutaminase 1 |
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7-02859 | CHI Scientific | 1mg | Ask for price |
E.Coli Glutaminase 1 (Recombinant) |
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20-abx073219 | Abbexa |
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Recombinant Glutaminase 2 (GLS2) |
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RPJ025Mu01 | Cloud-Clone | 10ug | EUR 172 |
Recombinant Glutaminase 2 (GLS2) |
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4-RPJ025Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Glutaminase 2 expressed in: E.coli |
Recombinant Glutaminase 2 (GLS2) |
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RPU57655-100ug | Biomatik Corporation | 100ug | EUR 470.4 |
Recombinant Glutaminase 2 (GLS2) |
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RPU57655-1mg | Biomatik Corporation | 1mg | EUR 2184 |
Recombinant Glutaminase 2 (GLS2) |
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RPU57655-50ug | Biomatik Corporation | 50ug | EUR 385 |
Recombinant Glutaminase 2 (GLS2) |
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RPU52739-100ug | Biomatik Corporation | 100ug | EUR 530.2 |
Recombinant Glutaminase 2 (GLS2) |
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RPU52739-1mg | Biomatik Corporation | 1mg | EUR 2347.8 |
Recombinant Glutaminase 2 (GLS2) |
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RPU52739-50ug | Biomatik Corporation | 50ug | EUR 425.7 |
Glutaminase 1 E.Coli Recombinant |
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rAP-1378 | Angio Proteomie | Inquiry | Ask for price |
Glutaminase recombinant monoclonal antibody |
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A5125 | Bimake | 100ul X 3 | EUR 714 |
Description: A recombinant monoclonal antibody from rabbit against human Glutaminase for WB, IHC, IF,ELISA |
Recombinant Aeromonas Salmonicida Glutaminase (aa 1-306) |
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VAng-Lsx1092-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 5212.8 |
Description: Aeromonas Salmonicida Glutaminase (aa 1-306), recombinant protein. |
Recombinant Aeromonas Salmonicida Glutaminase (aa 1-306) |
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VAng-Lsx1092-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 3528 |
Description: Aeromonas Salmonicida Glutaminase (aa 1-306), recombinant protein. |
Recombinant Aeromonas Salmonicida Glutaminase (aa 1-306) |
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VAng-Lsx1092-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 2404.8 |
Description: Aeromonas Salmonicida Glutaminase (aa 1-306), recombinant protein. |
GLSA1 Glutaminase 1 E.Coli Recombinant Protein |
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PROTP77454 | BosterBio | Regular: 20ug | EUR 380.4 |
Description: GLSA1 E.Coli Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 330 amino acids (1-310a.a.) and having a molecular mass of 35.0kDa. ;The GLSA1 is purified by proprietary chromatographic techniques. |
Recombinant Escherichia coli Glutaminase 1 (glsA1) |
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CSB-EP302868ENV | Cusabio | 2617 mg | Ask for price |
Recombinant Escherichia coli Glutaminase 1(glsA1) |
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AP77558 | SAB | 1mg | EUR 2826 |
Recombinant purified Glutaminase 1 (ybaS, E. Coli, his-tag) |
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RP-1622 | Alpha Diagnostics | 20 ug | EUR 416.4 |
Recombinant E.coli Glutaminase 1 Protein, His-GST, E.coli-1mg |
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QP6951-1mg | EnQuireBio | 1mg | EUR 1448.4 |
Recombinant E.coli Glutaminase 1 Protein, His-GST, E.coli-10ug |
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QP6951-10ug | EnQuireBio | 10ug | EUR 186 |
Recombinant E.coli Glutaminase 1 Protein, His-GST, E.coli-50ug |
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QP6951-50ug | EnQuireBio | 50ug | EUR 316.8 |
Recombinant E.coli Glutaminase 1 Protein, His-GST, E.coli-100ug |
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QP6951-100ug | EnQuireBio | 100ug | EUR 403.2 |
Recombinant E.coli Glutaminase 1 Protein, His-GST, E.coli-200ug |
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QP6951-200ug | EnQuireBio | 200ug | EUR 523.2 |
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The Salmonella strains from sick animals contained varied SPIs, resistance genes and plasmid varieties primarily based on the serotype and supply of the isolates. Such sophisticated genomic constructions make clear the pressure traits contributing to the severity of illness and therapy failures in Salmonella infections, together with these inflicting diseases in animals.
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